pI: 7.8237 |
Length (AA): 139 |
MW (Da): 15396 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
11 | 135 | 4bum (X) | 200 | 281 | 34.00 | 0 | 0.08 | 0.397981 | 2.71 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127746)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G57490 | voltage dependent anion channel 4 |
Arabidopsis thaliana | AT3G01280 | voltage dependent anion channel 1 |
Arabidopsis thaliana | AT5G15090 | voltage dependent anion channel 3 |
Brugia malayi | Bm1_31685 | Probable voltage-dependent anion-selective channel, putative |
Candida albicans | CaO19.1042 | outer mitochondrial membrane porin |
Candida albicans | CaO19.8644 | outer mitochondrial membrane porin |
Caenorhabditis elegans | CELE_R05G6.7 | Protein R05G6.7 |
Drosophila melanogaster | Dmel_CG6647 | CG6647 gene product from transcript CG6647-RB |
Echinococcus granulosus | EgrG_000297500 | voltage dependent anion channel protein 2 |
Echinococcus multilocularis | EmuJ_000297500 | voltage dependent anion channel protein 2 |
Homo sapiens | ENSG00000165637 | voltage-dependent anion channel 2 |
Homo sapiens | ENSG00000078668 | voltage-dependent anion channel 3 |
Homo sapiens | ENSG00000213585 | voltage-dependent anion channel 1 |
Loa Loa (eye worm) | LOAG_00456 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08386 | hypothetical protein |
Mus musculus | ENSMUSG00000020402 | voltage-dependent anion channel 1 |
Mus musculus | ENSMUSG00000021771 | voltage-dependent anion channel 2 |
Mus musculus | ENSMUSG00000008892 | voltage-dependent anion channel 3 |
Oryza sativa | 4331551 | Os03g0137500 |
Oryza sativa | 4339446 | Os05g0536200 |
Oryza sativa | 4346851 | Os09g0361400 |
Oryza sativa | 4327665 | Os01g0588200 |
Saccharomyces cerevisiae | YNL055C | Por1p |
Saccharomyces cerevisiae | YIL114C | Por2p |
Schistosoma japonicum | Sjp_0200380 | ko:K05862 voltage-dependent anion channel, putative |
Schistosoma japonicum | Sjp_0103420 | ko:K05862 voltage-dependent anion channel, putative |
Schistosoma mansoni | Smp_022990 | voltage-dependent anion-selective channel |
Schistosoma mansoni | Smp_091240.1 | voltage-dependent anion-selective channel |
Schistosoma mansoni | Smp_091240.2 | voltage-dependent anion-selective channel |
Schmidtea mediterranea | mk4.005932.02 | Probable voltage-dependent anion-selective channel |
Schmidtea mediterranea | mk4.001243.09 | |
Schmidtea mediterranea | mk4.002888.00 | Probable voltage-dependent anion-selective channel |
Schmidtea mediterranea | mk4.009747.01 | |
Schmidtea mediterranea | mk4.006211.00 | |
Schmidtea mediterranea | mk4.009747.00 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | voltage-dependent anion channel 2 | Compounds | References |